insomnia nights: fighting imaginary battles

Photo from wiki

Since I get insomnia a lot and end up writing a lot of blog posts between 1 and 4am, I figured I’d start a series called “insomnia nights” which will feature the weird places my mind goes during my nighttime forays. Now, with that established, let’s begin the most recent compilation of thoughts.

Sometimes I worry that Fiona will get eczema. It’s not that I worry inherently because eczema is this horrible life sentence or anything, but I worry that she’ll get pulled into a world of quick-fix medications and will end up down the road looking and feeling like me. She’s got such lovely baby skin (minus the occasional acne… did you know that babies get acne?!), that I just want to make sure she gets half a chance to keep it. 

Now this fear is also blatantly ignoring all the progress that is developing in the eczema treatment world. Like not all doctors (just all the ones I’ve seen) push steroids as their first line of defense. And naturally I would push back at anyone that tried to get me to slather creamy crack on an infant (is a 5 month old baby still considered an infant?). But at the same time, it would be nice if I didn’t have to prep for a fight.

But as neither of these things has happened yet (Fi getting eczema or me fighting her future dermatologists for less reactionary medicines), essentially this post is all about me and my imaginary battles. It’s good to know I am firmly rooted in reality in my day to day (or should I say night to night) insomnia life.

Continuing on about imaginary battles, I have a really weird way of going about reading books. I still have a library pile that has looming due date deadlines that I hope to meet, but I am being slowed by the amount of health-related books I got that I just can’t get myself to chug through. There are certain styles of writing that I really enjoy consuming, but lately all the books I’ve gotten in the health-esque field are not of that style. They are often overly repetitive, which drives me nuts. If I have to read page after page where you are going to say the same thing, I should just commit to the first paragraph of each chapter and move on! But of course I can’t actually do that; I pigheadedly must finish them thus, there we have the the “imaginary battle” bit.

At the moment I am stuck with this one book on obesity, but have started seeing another book on the side. Yes, I know that’s cheating but I need to find some pleasure in reading here! I just finished this book called Worlds of Childhood: The Art and Craft of Writing for Children, and it features the commentary of six children’s authors who talk about why they write, how they got into writing about said book topics, and just generally gives a taste of their process and their mentalities. It’s AWESOME. It’s quite inspiring and makes me want to write children’s books but I’ll table that idea for another day because lord knows I am already too easily inspired by what I read.

Also the power went off last night. I know this because Fi woke me up during the outage and then I had to make sure to put her in more layers as we didn’t know how long the heat would be off. That thought then made me realize I may not be able to take a bath/shower when I got up, which was a terrifying thought. I rely on such morning methods to help remove the newest skin exoskeleton I have acquired over night and to help wet the skin so applying moisturizer does something besides lotion-coat dead skin. It’s crazy how much eczema requires me to be dependent. I need central heat control and access to hot water plumbing and places to curl up in a ball from insomnia exhaustion. Not to mention the large amount of products I try out and go through. So then I had to plan out my battle strategy for having no shower/bath, which basically came down to me asking Jake if he thoughts power would be back on by the time I “woke up”.

Speaking of products, as my hands have been cracking quite badly overnight, I decided to try out liquid bandaids (because regular ones won’t adhere to my dry skin, and they certainly can’t stick to my skin if I’m covered in moisturizer). So there I am trying out these bandaids and oh my frick do they burn. I mean they smell like acetone (think nail polish remover), so I don’t know why I’m surprised, but holy hellabore they are not fun to apply. They basically act like glue and pull the skin back together, which is great, save for the fact that most of the cuts are on my knuckles, so bending my fingers pops the glue seal. Oh well. At least I felt a little less dried out today (…or yesterday. Time is a relative thing when you insomnia blog but don’t post actually get around to posting anything until a day or two later). If these liquid bandaids lead to great healing, well then the momentary application pain is worth it. I can firmly say, having continued this post the next night, that the bandaids did not lead to great healing. Oh well.

Well here I am again writing at 2am. Fi woke up to feed around 1am and now my mind is still trudging along. It’s not randomly snowing tonight so instead of having that magical snow-covered lightness about the world, I’m over here like this guinea pig (on the right). That video cracks Jake up every time. In fact I’ll know if he reads my post tomorrow because I’ll hear hysterical laughter-induced coughing if so. No pressure, Jake. I’ll just be low-key waiting for that as proof that you read my posts. 

Anyway tonight I’m trying an experiment where I just keep on re-applying moisturizer whenever Fi wakes me up, especially to my hands. So far my hands do feel softer, but it’s not stopping them from drying the evergreen out, or from the skin of my knuckles cracking like the grand canyon did long ago. But I’ll persevere and assess the progress in the morning. Later morning I mean. Until then I’ll continue to battle my overnight fissuring skin tendencies. It’s me versus moisture-loss.  Who will win? Place your bets in the comments below! 

cultivating simple pleasures

pexels-photo-92612.jpeg
Photo by Matthias Zomer on Pexels.com

Today’s post is silly and short.

I remember the reoccurring theme in the French movie Amélie when the narrator tells us what each of the characters likes and dislikes. Because the protagonist Amélie grew up with no friends, she was said to have learned to cultivate an appreciation for the finer things in life, like collecting smooth stones for skipping, sliding her fingers into large burlap sacks of dried beans, and cracking freshly made crème brulée.

Well I too have devised my own version of weirdly satisfying simple pleasures for one living with eczema that I will share with you all so you can all be tantalized by these delicious (and mostly improbable) thoughts. Sorry if some of them are gross; I have a weird mind.

And so, without further ado, my current running list of cultivated simple eczema pleasures:

  • Dipping eczema flaky feet into those ponds of fish that lightly nibble dead skin.
  • Getting Elmer’s white glue all over the top of the hands and then pulling off the dried result (like we did as kids to our palms), and watching the dead skin pieces go with it.
  • Getting a Korean exfoliation skin massage and watching the bits of skin slew off (if this didn’t entail probably wrecking eczema-afflicted skin).
  • Having a lint roller for dead skin that can just roll the excess skin away.
  • Going into a mud bath equivalent of what was in the movie Spirited Away, and coming out all silky smooth as the mud deeply moisturized the skin cracks.

Then I have ideas for all these even more so crazy impossible scenarios, like a skin cheese peeler that only goes as deep as the dead cells and doesn’t hurt any new skin growth, and other weird things like that.

Clearly I’m feeling flaky these days. I’ve started to identify the fall season time as being when I identify most with a bear. I alternate between just wanting to roll up in blankets and hibernate for months and wanting to emerge to rub my itchy body on trees.

pole-dancing-bear.gif

Yeah, that’s me in a nutshell. Bears get me.

sometimes i personify my eczema

pexels-photo-987585.jpeg
Photo by freestocks.org on Pexels.com

When I haven’t had a real flare in a while (flare in my case depicted by aggressive heating up randomly due to pressure or any prolonged skin contact, or when my skin develops a hot red undertone color), its timely arrival always knocks me down a few notches. Sometimes I liken my eczema to being some kind of monster that continues to hunt me movie after movie sequel, or I hear its irritating voice cutting through a crowd. This most recent flare comes across like a socially unaware drunk, and I like to lighten my mood by pretending it would act like Sheldon from The Big Bang Theory:

tenor.gif

Ugh. At any rate, I’m taking it day by day, and the good news is when I do fall asleep (and Fiona doesn’t wake me up) I can really sleep, thankfully. It’s strange, I don’t really remember what it’s like to naturally wake up anymore. In the immortal words of country singer Thomas Rhett, “ain’t it funny how life changes”.

But, when I am first in bed, sandwiched between the time before I can succumb to the depths of the dream world and the time before Fi wakes me up again, my head is filled with thoughts that I have to process.

It’s during this time that I find that I tend to blame myself for my flares. I’ll think back to things I ate and worriedly wonder if it was sunflower oil in the crackers causing me to develop a sensitivity to my moisturizers that have sunflower in them. Or I’ll berade myself because I had the fruit covered in dark chocolate. I’ll panic that I’m secretly allergic (but not anaphylaxically) to almonds and just never knew, or that it’s because I had too many calories and ate too many legumes and so I slugged my digestive system down and now I am paying the price. Or maybe I had a Polar Seltzer and who knows what those natural flavors are made of! Or I had a probiotic drink and maybe it was the wrong kind of probiotics. What if it was the coconut!? At any rate, the result is always the same, fearing food and feeling blue about myself.

This type of stress gets compounded by my clingy eczema, as it lingers over me constantly reminding me that there is a cause to each flare-up, so what was it this time? I also find that I scratch my hands a lot more at night from a combination of the heating up moments laying under the blankets along with the constant drying out (and literally nothing keeps the moisture in at this stage!).

What I’ve learned is that when I get super tired in the middle of the night, as I’m pawing away at my paws, I tend to have thoughts zoom around my head that make no sense but seem so logical in the moment. If I just scratch here then you know that assignment will get done. And random nonsensical thoughts like that. I honestly have no idea what I’m talking about when I wake up in the morning and looking at my picked scabs and scratch marks.

When I do have some skin healing downtime, I like to map out how I’ll treat myself later. I know it’s a pretty divisive option, but I love tattoos. I think there is something about knowing my skin gets all wrinkly and cracked and flaky that makes me not have those “well imagine how bad it will look when you are old and wrinkly” thoughts. I’m already wrinkly, and age has nothing to do with it. Me and this cat are basically identical:

giphy

At any rate, I like to find cleared spots and think about what kind of tattoo I would get there. Lately I’ve been thinking about lotuses. They have a lot of symbolism for women’s health which I really like. That and I really want to get a tattoo of a open book at some point. Generally I like dreaming this up a lot more than I actually execute action, but who knows what will happen after this flare passes.

 

 

do you detox? (or fast? or supplement?)

sliced lemons
Photo by rawpixel.com on Pexels.com

“Hello darkness my old friend”… today’s post was started during the witching hours of the night, not because of insomnia (yay, progress!) but because of Fi-somnia… aka my 4.5 month old baby, Fiona. She’s a much cuter reason to have a disturbed REM cycle.

Anyway let’s talk about the health elephant in the room: detoxing. I have heard more and more talk about various detoxification methods and I am just not sure what it all means, so today’s post is about clearing my system (pun intended) of these questions.

First off, what are the theories around detoxification? One theory I have heard for those who have eczema goes as followed: our organs (specifically the liver and kidneys) become over-taxed by our modern diets and exposure to heavy metals and other toxins, and at some point it becomes all too much and our bodies cannot flush-out said toxins, so instead, the build-up of toxins show off their toxic love by wrecking our skin.

Now going by that theory, let’s quickly delve into the soup to nuts details of how detoxification works in the body in general by addressing (very quickly) specific organs.

  • Liver: works by changing toxins into less harmful substances and/or helping the body flush out toxins
  • Kidneys: remove waste and acid build-ups from blood into our urine to be flushed out of the body
  • Intestines: helps to remove toxins via waste or vomit
  • Lymph system: transports its white blood cells throughout the body
  • Respiratory tract: the lungs remove gases from our bodies
  • Skin: (when intact) prevents some toxins from penetrating into the body

So from there, let’s address some specific detox methods I’ve heard about including the watermelon detox, the lemon detox, etc. My internet researching first led me to a review done in 2014, which reported that there wasn’t much evidence to show that detox diets actually work. It indicated that studies that said otherwise usually had flaws in their methods or too few people tested (aka small sample sizes, which is a problem because then you can’t reasonably assume the results will work for a much larger group).

I then looked more for studies, but before I talk about them, let’s backtrack and talk about studies that investigated how detoxification naturally works in the human body (and/or animal bodies). First I wanted to figure out what organs have been studied to hold toxins. A study done in 2007 on African catfish showed how the livers, kidneys, and hearts of the fish ended up storing high concentrations of heavy metals (zinc, lead, arsenite, cadmium, and copper) presumably from pollution entering the water nearby. I’m not sure if the same organs are seen to hold toxins in the case with humans, but given how often we hear livers talked about in the same sentence as detox diets, I’d venture to say yes. I then actually looked up via the CDC, about organs and toxic exposures for humans, and apparently all organs can be affected. Well then, how do our bodies avoid full spectrum toxicity?

Well, bodies have some ability to create compounds out of heavy metals, to bind them chemically to make them less dangerous to the body (which is the function of the liver, remember?), as was supported in a study in 2004 on seals, porpoises, and albatross. Generally heavy metals can end up in cells in the body: in the cell’s fluid, mitochondria, nucleus, etc (in the case of the study, they were talking about liver cells). But how specifically do bodies deal with heavy metals; or in other words, what gets the liver to start neutralizing these toxins? A study done in 2004 on mice looked at something called the metal responsive transcription factor 1 (or MTF-1)Side note: a transcription factor is a protein that helps turn on/off genes. The study’s results showed that a developing fetus that lacks Mtf1 (the gene that MTF-1 can turn on/off) will die because its liver won’t be able to form properly, but an adult that lacks Mtf1 will have difficulty handling heavy metals and will have low lymphocytes (the cells that help clear bad germs and materials out of our blood). This MTF-1 also is used to deal with when the body has hypoxia (not enough oxygen) or oxidative stress (too many free radicals in the body). What this all means is that our liver is able to function properly because it has this protein that turns on whatever genes are needed to get the liver to deal with toxins (metals and free radicals).

Now let me also quickly talk about oxidative stress, which is important to note because heavy metals can cause oxidative stress. That may be why and where the idea of some detox diets came from: if you want to detox from free radicals in the body, doesn’t it seem logical to consume antioxidant-rich foods and nothing else for a few days to cleanse? And what foods are known to have good supplies of antioxidants? Watermelons, lemons, and many fruits and vegetables that we see juiced into detox juices. So using that line of thinking I now move on to trying to better understand the support behind specific cleanses.

First I searched for the lemon detox. There’s a study that was done in 2015 on overweight Korean women that tested the lemon detox drink (a lemon, maple syrup, and palm syrup combo) versus a placebo drink versus a normal diet for 7 days followed by 4 days of food transition. According to the abstract of the study (which was all I could access freely) both the placebo and lemon drink resulted in improved BMI, body weight and body fat, as a well as improved serum insulin levels and insulin resistance scores. Hemoglobin and hematocrit levels were unchanged for those on the lemon diet, while a protein called serum high-sensitive C-reactive protein (hs-CRP) was reduced. What I am unsure of, is if the hematocrit and hemoglobin levels were within a normal range to start for the participants (which is important to know because too low indicates issues like anemia/low iron in the blood; too high can be a signal of dehydration among other things). The researchers concluded that going on a lemon drink detox for 7 days improves body fat and insulin resistance. The reasoning behind why however, they said was because the lemon detox drink is low-calorie, so essentially you are just burdening your digestive system less. So it’s more likely the fasting component that helps rather than the lemon drink having a cleansing effect.

What about watermelon? A study done on rats in 2015 indicated that a diet of watermelon helped reduce the effects of laboratory-induced type 1 diabetes. The procedure involved the rats fasting for 24 hours before being injected with a solution (alloxan) to induce diabetes, and then being fed watermelon extracts for a week. The rats given the watermelon extract had improved weights and reduced blood glucose concentrations, among others changes that caused the watermelon-fed rats to more closely resemble the control (healthy) rats, than the diabetic rats.

Thus my overall concluding thoughts on detoxing so far, are that:

  1. If you are consuming fewer calories, innately you are taxing your digestive system less so you’ll have a natural “detox” effect,
  2. With fewer things in your digestive system, the effects of consuming foods that are rich in antioxidants probably does help remove free radicals. It also probably therefore lets your liver bind toxins and your kidneys remove waste more effectively, and
  3. If detoxing is therefore being used synonymously with fasting, then there is a lot of evidence that it works. Fasting has been studied to, when done safely, be beneficial for everything from diabetes and obesity to other autoimmune disorders.

The reason I brought up point number 3 is because there are studies done on lemon juice and other popular detox foods that don’t include fasting, but rather just adding said food to a person’s existing diet. One such study done in 2016 tried such an experiment, by adding lemon juice and garlic to participants diets, and their results included decreased cholesterol, reduced blood pressure, and reduced BMI. In Jason Fung’s book Obesity Code, he mentions how drinking two tablespoons of apple cider vinegar in water before bed helps lower your blood sugar levels while you sleep. So then one can beg the question of, are we seeing improvements to health more so because fasting allows our bodies to “catch up” and get rid of toxins, or because we are lacking nutrients and so when we supplement them we see positive outcomes to our health?

Backtracking for one last comment on juicing and raw vegetable/fruit detoxing. A study done in 2017 looked at the effects of a raw juice diet of 6 drinks a day for 3 days, varying the juices throughout, and saw a lot of positive results in changes to the gut microbiota, increasing microbiome species correlated with weight loss and other aspects. The issue still stands of whether or not it’s the food types themselves that are included in the juices, or the fasting aspect (as one consumes a lot fewer calories when juicing), that provokes said positive results.

Honestly, in my humble opinion, it doesn’t actually matter which answer is correct because if you are safely fasting on occasion (and/or reducing calories), and consuming healthy options with lots of vitamins and minerals while doing so, does it really matter which aspect is to praise for the good results?

Ending note: I hope this was apparent, but, the intention of this post isn’t to target people who do or don’t do detoxing juice diets but merely to satisfy my curiosity. I had heard a lot of anecdotal experiences on the matter and so I was curious to hear about the results from more formal studies as well. Whether or not you choose to juice is your own prerogative.

 

REFERENCES

Aslani N, Entezari MH, Askari G, Maghsoudi Z, Maracy MR. Effect of Garlic and Lemon Juice Mixture on Lipid Profile and Some Cardiovascular Risk Factors in People 30-60 Years Old with Moderate Hyperlipidaemia: A Randomized Clinical Trial. Int J Prev Med. 2016; 7: 95.

“Detoxification.” Partnership for Environmental Education and Rural Health, https://peer.tamu.edu/curriculum_modules/OrganSystems/Module_3/index.htm. Accessed 7 Nov 2018.

Farombi EO, Adelowo OA, Ajimoko YR. Biomarkers of Oxidative Stress and Heavy Metal Levels as Indicators of Environmental Pollution in African Cat Fish (Claris gariepinus) from Nigeria Ogun River. Int J Environ Res Public Health. 2007; 4(2): 158-165.

Henning, SM, Yan J, Shao P, Lee R, Huang J, Ly A, Hsu M, Lu Q, Thames G, Heber D, Li Z. Health benefit of vegetable/fruit juice-based diet: Role of microbiome. Scientific Reports. 2017 May 19; 7.

“How does the liver work?” Informed health Online, Institute for Quality and Efficiency in Health Care, https://www.ncbi.nlm.nih.gov/books/NBK279393/. Accessed 6 Nov 2018.

Ikemoto T, Kunito T, Tanaka H, Baba N, Miyazaki N, Tanabe S. Detoxification Mechanism of Heavy Metals in Marine Mammals and Seabirds: Interaction of Selenium with Mercury, Silver, Copper, Zinc, and Cadmium in Liver. Archives of Environmental Contamination and Toxicology. 2004 Sep; 47(3): 402-413.

Kim MJ, Hwang JH, Ko, HJ, Na, HB, Kim JH. Lemon detox diet reduced body fat, insulin resistance, and serum hs-CRP level without hematological changes in overweight Korean women. Nutrition Research. 2015 May; 35(5): 409-420.

Klein AV, Kiat H. Detox diets for toxin elimination and weight management: a critical review of the evidence. Journal of Human Nutrition and Dietetics. 2015 Dec; 28(6): 675-686.

Oseni OA, Odesanmi OE, Oladele FC. Antioxidative and antidiabetic activities of watermelon (Citrullus lanatus) juice on oxidative stress in alloxan-induced diabetic male Wistar albino rats. Niger Med J. 2015 Jul-Aug; 56(4): 272-277.

“Taking an Exposure History: Which Organ Systems Are Affected By Toxic Exposure(s)?” Agency for Toxic Substances & Disease Registry: Environmental Health and Medicine Education, https://www.atsdr.cdc.gov/csem/csem.asp?csem=33&po=6. Accessed 6 Nov 2018.

“Transcription factors.” Khan Academy, https://www.khanacademy.org/science/biology/gene-regulation/gene-regulation-in-eukaryotes/a/eukaryotic-transcription-factors. Accessed 7 Nov 2018.

Wang Y, Wimmer U, Lichtlen P, Inderbitzin D, Stieger B, Meier PJ, Hunziker L, Stallmach T, Forrer R, Rülicke T. Metal-responsive transcription factor-1 (MTF-1) is essential for embryonic liver development and heavy metal detoxification in the adult liver. The FASEB Journal. 2004 Jul 1; 18(10). 

“Your Kidneys & How They Work.” National Institute of Diabetes and Digestive and Kidney Diseases. https://www.niddk.nih.gov/health-information/kidney-disease/kidneys-how-they-work. Accessed 6 Nov 2018.

why you might want to follow news on filaggrin

yellow health medicine wellness
Photo by Pixabay on Pexels.com

I mentioned in a post last week that I was reading a book called Living with Itch by doctors Gil Yosipovitch and Shawn G. Kwatra. Well I’ve since finished it and determined it’s another book that I think everyone should read.

While reading said book I came to the following image:

2018-10-28 09.50.04

As I stared at my own palms, which do look remarkably like that illustration (as in I would make a palm reader dizzy trying to interpret all my lines), I pondered about this protein, filaggrin, and about all of us filaggrin-lacking individuals. This led me to wonder if there were existing treatments out there to replace filaggrin in those deficient.

But first, I had to understand what filaggrin does. Cue google scholar searching for studies! Filaggrin is a protein that binds keratin fibers together. Keratin is the protein that helps create the structure of the outer layer of our skin (and nails and other things). So not having functioning filaggrin means that outer skin barrier is not as strong and impervious to the external environment (germs, mechanical stressors like scratching, chemicals, temperature, water retention, etc).

Armed with that knowledge I did a cursory search which brought me to two studies, one in 2014, and one brand spanking new one done this year. The 2014 one looked into filaggrin injections, but I’m getting ahead of myself. To start, the study (done presumably in Europe as it talks about Europeans in particular and as I could only access the study’s abstract) gives background information that 1 in 10 European people have this filaggrin (FLG) loss of function mutation (or what they call a LOF mutation) and that so far this LOF mutation is the biggest genetic risk of atopic dermatitis. They also give other fun likelihoods like that someone with said mutation is more likely ” to develop asthma, to have more severe and more persistent disease, to have allergic sensitizations, and to develop eczema herpeticum”. At this point you may be thinking, ‘all of us FLG LOF’ers are off to a rough start!’ The study then went on to describe why they think filaggrin replacement therapy may help with eczema management (specifically atopic dermatitis, but I’m going to continue using the blanket term of eczema from now on). Basically they talk about how gene replacement therapy of this protein is difficult because the protein is so large and they need to get it through the stratum corner layer of the skin into the cytoplasmic space for it to work. So instead of trying to inject the big protein into the skin, they did some science-magic and used some mouse genetic material linked to a compound that could penetrate cells (a peptide) to make a recombinant protein (which can help get a mutant gene to express the normal function, in this case getting filaggrin to bind keratin fibers together). They tested their work on cell cultures, flaky mice tails, and human skin equivalents and results showed that the flaky tails’ stratum corneum (the outermost layer of the skin) seemed to be restored. They ended the study by saying that there would need to be further studies to determine how safe this would be for humans, as well as things like how much to use, how well it works, and how long to use it, etc. They also noted that though mice didn’t have any problems with the foreign protein injected into their tails, that there is still a possibility that humans’ skin/immune system could reject the forgiven material.

The newer study, rather than trying to inject filaggrin into the skin, took the approach of trying to create a nutritional supplemental to ingest (as they were particularly interested in making a convenient and safe treatment, especially for children). They noted that an amino acid called L-histidine gets used in filaggrin production, and when the filaggrin gets broken down, the L-histidine is released and used as a natural-moisturizing factor (or NMF) and is said to “contribute to barrier function through skin hydration and maintenance of stratum corneum acidity” (hey look, skin acidity mentioned once again). This study also goes on to mention how eczema may be caused by either the FLG mutation or messed up profilaggrin processing but either way can lead to the skin barrier issues we see with eczema, and for either issue the L-histidine amino acid has a beneficial effect. Their overall results were that an L-histidine supplement once a day for 4 weeks showed positive changes to eczema and those benefits lasts even when the L-histidine was discontinued. They even said that their results indicated using the L-histidine was on par with using a mid-potency topical steroid while being steroid free (so none of the side effects)!

Both the L-histidine supplement and the filaggrin injection sound extremely promising and exciting for the world of people living with eczema, though I, in particular am leaning towards the supplement, if I had my pick (I would love to be part of the study for L-histidine, but that will have to wait until I’m done breastfeeding).

 

REFERENCES

Irvine AD. Crossing Barriers; Restoring Function? Filaggrin Protein Replacement Takes a Bow. Journal of Investigative Dermatology. 2014 Feb; 134(2): 313-314.

Sandilands A, Sutherland C, Irvine AD, McLean WHI. Filaggrin in the frontline: role in skin barrier function and disease. J Cell Sci. 2009; 122: 1285-1294. 

Tan SP, Brown SB, Griffiths CEM, Weller RB, Gibbs NK. Feeding filaggrin: effects of L-histidine supplementation in atopic dermatitis. Clin Cosmet Investig Dermatol. 2017; 10: 403-411.

hot flashes with a side of holidays

close up creepy dark darkness
Photo by Toni Cuenca on Pexels.com

Happy belated Halloween! Yes, I know I’m a day late but I’m including other holidays to pad my belated holiday post.

I started writing this at 3am on Halloween, and boy was I feeling it. I’d say I was doing about as well as an old cracking, stiff black leather couch on a dry heat kind of day when hot human flesh sprawls on top it (aka I was both drying out and exuding an uncomfortable amount of heat). To compound that, Fi kept waking up around every 2 hours, and it takes me at least 15-45 minutes to go back to sleep after she’s cared for, so deep healing sleep was not in my repertoire the other night, folks.

And so, instead of sleeping, I got all ready to chat about my once favorite holiday, Halloween. Did I mention how I absolutely love to dress up (or did before my skin started raging against the machine that is my body)? Anyway, I truly believe this day (or days) of year is (are) incredibly magical. For one, there are so many different cultural holidays, from our Halloween roots of Samhain, to All Saints’ Day to Latin America’s Día de los Muertos, to harvest festivals, to Guy Fawkes Day, etc.

Let’s start with the American classic holiday, Halloween. We all know how the holiday is celebrated today, at least in North America (though I’ve got a fun example of how it’s changing in an eczema-friendly direction that I’ll talk about later in the post), so for now let’s skip back a few decades to talk about Halloween’s origins.

Here’s the shortened history. Halloween had its roots from the Celtic festival Samhain, a celebration of the end of summer and the start of the harvest season. Because of the weather changes from summer to winter, it was also believed that this was a time when the worlds of the living and the death overlapped, and spirits could return to earth. To celebrate, the Celtic priests (Druids) made large bonfires where people brought sacrifices from their farm production, and they dressed up in animal skins. When the Roman Empire conquered the Celtic territory, they introduced other festivals that blended into our current holiday lore, such as commemorating the dead and festivals of fruit and trees (one which may have inspired the old tradition of bobbing for apples). The blending of Christianity into the Celtic territories led to holidays like All Souls’ Day, which was like Samhain but people dressed up as angels, devils, and saints, and eventually All Saints Day was moved to November 1st and Samhain (which became All Hallows Eve, and then Halloween) became the night before or October 31st. Halloween in America started out more similarly to the harvest festivals, then formed into an amalgam of folklore, ghost stories, mischief, and asking for treats. Over time it was reformed to try to be more community-based with parties, and with treats being given out to avoid tricks becoming the norm. At some point costumes were encouraged, first as a way to deter roaming spirit from recognizing living people, and then it was more for fun as it was modernized to what we know it as today.

Speaking of modernizing, there’s a new version of Sabrina the Teenaged Witch redone as a Netflix original (called Chilling Adventures of Sabrina) that definitely takes a much darker take on the 90s sitcom. In it, Sabrina is a half-witch, half-mortal who is constantly taking on the patriarchy, which is particularly creative when the patriarchy in question is not always that of humanity. But that’s where I’ll stop just in case anyone is planning on watching it (noting that some of the themes and violence are not appropriate for young children). If I were to try to liken the show’s general theme to that of eczema, I’d say it would be that you should always feel free to fight to create your own space, your own identity, and your own world even when the options seem to be telling you that you have a limited amount of choice. I’d elaborate more but I’m trying not to give away too many thematic spoilers.

And as promised, here’s a fun eczema-friendly movement that’s developed. Called the Teal Pumpkin Project, it’s a movement that is in recognition of the growing amount of life-threatening food allergies. Pioneered by a mom named Becky Basalone from Tennessee in 2012, she painted a pumpkin teal to indicate that she would offer alternatives to candy on Halloween, as her son had anaphylaxis and she wanted to have a way for him to still enjoy the holiday without worry. The Food Allergy Research and Education organization picked up the Teal Pumpkin Project and helped it gain country-wide recognition in 2014, encouraging people around the nation to put out these teal pumpkins to let families know that there are allergy-free (non-edible) treats available. So now, for those children out there that may be going through some sort of systematic inflammation disorder (be it food allergies, eczema, or something else), they also have a way to still partake in the festivities of All Hallow’s Eve. If you want to be involved, you can paint a pumpkin teal and put it outside your house, and then add your house to the teal pumpkin project map.

FARE_TPP_NOURL

Now for Día de los Muertos (or Day of the Dead). This holiday has seen an increase in recognition in the states over the years (just look at movies such as Book of Life, or the newer Disney movie Coco). It entails a celebration of one’s deceased, honoring their lives by creating an ofrenda (or offerings) for them of food, flowers, colorful skeletons, and people don brightly colored clothing and have parades and music and festivities to celebrate their family. The belief (of which developed from a mix of Aztec culture and Catholicism) is that on the Day of the Dead one’s ancestors come back to visit on earth, but it is disrespectful to grieve for one’s deceased, so instead it is a day of reunion and remembrance and happiness.

And lastly we have Guy Fawkes Day. Many of you may be familiar with this holiday due to the 2006 movie V for Vendetta, that centers around this elusive date of November 5th (easily remembered by the ditty: “remember remember the 5th of November, the gunpowder treason and plot. I know of no reason why the gunpowder treason should ever be forgot.” The history behind this holiday was that under various monarchs in England, (but primarily under King James I’s rule), Catholics were persecuted, unable to marry, fined for refusing to attend non-Catholic services, etc. Various attempts to overthrow the ruling king were enacted but the most famous was that done by Guy Fawkes and company. Their plan was to use gunpowder to blow up parliament on November 5th, 1605. Somehow, a letter was delivered to parliament about the plot, and Fawkes was stopped November 4, and subsequently he and his team were sentenced to be drawn and quartered as punishment for high treason. Celebrations with bonfires started after the plot was revealed and November 5th became known as Guy Fawkes Day, (even spreading to America as Pope Day where people burned the Pope in effigy). Although America stopped celebrating their version, in Britain, Guy Fawkes Day entails (even today) bonfires, fireworks, parades, and of course, burning Fawkes in effigy. The holiday has taken a spin where Guy Fawkes is sometimes seen as a hero, a change which is attributed to the movie V for Vendetta, where V wears a Guy Fawkes mask as he attempts to topple a fascist government regime. Spoiler alert: in the movie, V goes on a last stand rampage to kill off the remaining “bad guys” and results in him sacrificing himself. While he is dying, he shares a “kiss” (put in quotes because the heroine, Evie, kisses his mask), and then he dies and she puts his body onto the train with all the explosives, that runs under parliament. Maybe if V had lived in this time period, instead of deciding to sacrifice himself he would have jumped into the bandwagon of #unhideECZEMA, but pioneered his own movement to be about unhiding burns, and then he could have removed the mask and gloves and found himself worthy of living a new life with Evie. But then there wouldn’t be a movie.

Speaking of movies, here’s a side note to end with (though it’s not family-friendly and it’s quite violent and whatnot): the movie Deadpool actually supports the idea really well of skin issues not being a big deal. Spoiler alert: Ryan Reynolds’ character Wade, aka Deadpool, becomes horribly disfigured from a mutant experiment and spends the first movie chasing after the psychopath doctor who did it to him to get the doctor to make him good-looking again before he is wiling to go back to see his beloved girlfriend/fiancée, Ness. When that plan ultimately fails and he is going to be forever scarred, he is still reunited with Ness and she is upset at him for wasting time away from her, but unfazed by his skin. The old adage holds true, love is goes deeper than skin deep.

And now here’s to me hoping my skin is cooler tonight and I can sleep.

 

REFERENCES

Born, Courtney. “Origin of the Teal Pumpkin Project- Interview with FACET’s Becky Basalone.” Living Allergic, https://www.allergicliving.com/2014/10/23/the-origin-of-the-teal-pumpkin-project-interview-with-becky-basalone-facet/. Accessed 30 Oct 2018.

Greenspan, Jesse. “Guy Fawkes Day: A Brief History.” History, https://www.history.com/news/guy-fawkes-day-a-brief-history. Accessed 30 Oct 2018.

“Halloween 2018.” History. https://www.history.com/topics/halloween/history-of-halloween. Accessed 30 Oct 2018.

Richman-Abdou, Kelly. “Día de los Muertos: How Mexico Celebrates Its Annual ‘Day of the Dead’.” My Modern Met, https://mymodernmet.com/dia-de-los-muertos-day-of-the-dead/. Accessed 1 Nov 2018.

what on earth is seed cycling?

black and brown peppercorns spilling from glass jar
Photo by Dids on Pexels.com

Today’s post may feel a bit out there, but that’s why it’s also nestled under my “miscellaneous” category. So, having absolved myself of all guilt for anyone who misinterprets this post as hard fact, I begin.

I recently saw the term ‘seed cycling’ used on social media and became intrigued as to one, what it meant, and two, what benefit it had (if any).

A quick Google search led me to both answers. Seed cycling is somewhat literally what it sounds like (although my first guess as it was 4am as I wrote this, involved interpreting cycling as bicycling). You cycle between seeds in your diet, consuming specific ones at specific types during your menstrual cycle (and supposedly it can be use for peri-menopausal and post-menopausal women as well).

Anyway, the theory is that a menstrual cycle is most naturally working if it is within the 28-day cycle, and anything else indicates some sort of imbalance of estrogen. The seeds chosen during the two phases of the menstrual cycle (when estrogen is decreasing and when it is increasing) are chosen specifically to help balance out the estrogen in each phase to allow the person to resume the natural cycle duration.

At this point you may be wondering why am I posting about this on my eczema blog? Well, you may recall from my post on pregnancy, that one of the factors believed to provoke eczema in pregnant women is the surge of estrogen. So my hypothesis is that if one’s cycle is off, and they experience larger ranges of estrogen surges during phases of their cycle, perhaps that would increase the intensity of an eczema flare.

Here’s a quick overview about the menstrual cycle (I previously worked as a women’s health consultant, so I both enjoy this kind of knowledge and could use the refresher myself). We have 4 phases: menstruation, the follicular phase, ovulation, and then the luteal phase.

  • MENSTRUATION – This is the phase in which the lining of the uterus (or the endometrium), which has thickened over the month, comes off and there is bleeding from the vagina.
  • FOLLICULAR PHASE – This phase starts on the first day of menstruation. The pituitary glands, triggered by the hypothalamus, release follicle stimulating hormone (FSH), and FSH in turn causes the ovaries to release a few follicles, each of which has an egg. One of these follicles’ eggs will start to mature, while the others die (around day 10). The uterine lining starts to thicken during this phase too due to follicular stimulation. The follicular growth also causes a surge in estrogen, which the body compensates for by the hypothalamus releasing gonadotrophin-releasing hormone (GnRH), which gets the pituitary gland to release lutenizing hormome (LH) and FSH.
  • OVULATION – During this phase, the high levels of LH triggers the release of the mature egg from the ovaries in two days. The egg is propelled by little hair-like structures through the fallopian tube into the uterus. Once there, it can survive for only about 24 hours. During this process, the egg has “hatched” out of the follicle, and the follicular remnant that gets dragged along outside the egg becomes the corpus luteum. The corpus luteum releases progesterone and a little estrogen, a mixture that helps keep the uterine lining thickened.
  • LUTEAL PHASE – During this phase the corpus luteum releases progesterone and a little estrogen, a mixture that helps keep the uterine lining thickened. When no pregnancy occurs, the corpus luteum falls off and dies (around day 22), causing a drop in progesterone. The progesterone drop triggers the uterine lining to fall off (aka menstruation), hence the cycle repeats.

So how does one do this seed cycling, you ask? Well, during the follicular phase (day 1 when you start to bleed to day 14) you take a daily dose of 1 tablespoon of ground flax/pumpkin/chia seeds. From days 15-28 you take a daily dose of tablespoon of ground sunflower/sesame seeds. That’s all there is to it.

But why is this supposed to work? I couldn’t find any rigorous studies on seed cycling, but came upon a blog post written by a naturopathic doctor (Dr. Lindsey Jesswein). She explains that the seed hulls have chemicals called lignans, which help “modulate hormone pathways”, and the seed oils (made of omega fatty acids) help “provide the building blocks for steroid hormone synthesis”. Jesswein then describes each seed (minus chia) a bit more by what they provide:

  • Flax – vitamin B, manganese,  and magnesium
  • Pumpkin – iron, magnesium phosphorous, zinc
  • Sesame – vitamin E, vitamin B1, manganese, irin, magnesium, copper, sesamin
  • Sunflower – vitmin E, linoleic acid, magnesium, potassium, zinc, calcium

The Herbal Academy (which was how I came to Dr. Jesswein blog post) goes into a bit more detail about the various benefits of each of these seeds and provided studies, but noted that the information was on individual seeds and not their impact with seed cycling.

A few of the studies they included (and some additional ones I found) found that:

Overall the evidence of large changes for the menstrual cycle is not huge, but at the same time, it generally doesn’t hurt to consume seeds in one’s diet so it may be worth trying if you want to play around with your nutrition (though always seek advice from a medical professional first, especially if you have a specific condition you are trying to treat!).

I’m curious to apply seed to myself so I might give it a trial for a few months and report back. Maybe. I’m also incredibly fickle, so probably not. I generally eat flax anyway with breakfast and the like, but I wouldn’t be able to notice if there were any changes because I’m still breastfeeding and thus not getting my period anyway.

Also I do understand that engaging in many different eczema projects simultaneously results in confounding the data as to which project individually helps my eczema, but it is my belief that eczema cannot be managed by just one miracle solution (though diet is a huge one) and so enacting multiple positive changes and approaches, so long as they are sustainable to myself lifestyle, I view as being the most maximally beneficial.

 

REFERENCES

Gossell-Williams, M., Hyde, C., Hunter, T., Simms-Stewart, D,. Fletcher, H., McGrowder, D., Walters, C.A. (2011). Improvement in HDL cholesterol in postmenopausal women supplemented with pumpkin seed oil: pilot study. Climacteric. 2011 Oct;14(5):558-64.

Hall, Annie. “Seed Cycling for Hormonal Balance.” Herbal Academy, https://theherbalacademy.com/seed-cycling-for-hormonal-balance/. Accessed 22 Oct 2018.

“Menstrual Cycle.” Better Health Channel, https://www.betterhealth.vic.gov.au/health/conditionsandtreatments/menstrual-cycle. Accessed 24 Oct 2018.

Phipps WR, Martini MC, Lampe JW, Slavin, JL, Kurzer MS. (1993). Effect of flax seed ingestion on the menstrual cycle. Journal of Clinical Endocrinology & Metabolism. 1993 Nov;77(5):1215 – 1219.

Somwanshi SB, Gaikwad VM, Dhamak KB, Gaware VM. Women’s Health Issue: A Brief Overview on Irregular Menstruation. IJNRD. 2017 May;7(5):2456-4184.

Troina AA, Figueiredo MS, Moura EG, Boaventura GT, Soares LL, Cardozo LFMF, Oliveira E, Lisboa PC, Passos MARF, Passos MCF. Maternal flaxseed diet during lactation alters milk composition and programs the offspring body composition, lipid profile and sexual function. Food and Chemical Toxicology, 2010 Fed;48(2):697-703.

Zaineddin AK, Buck K, Vrieling A, Heinz J., Flesch-Janys D, Linseisen, J, Chang-Claude J. (2012). The association between dietary lignans, phytoestrogen-rich foods, and fiber intake and postmenopausal breast cancer risk: a German case-control study. Nutrition and Cancer. 2012;64(5):652-65.